Hypoglycemic Effect of the Aromatic Water of Leaves of Ficus Carica In (ormal and Streptozotocin Induced Diabetic Rats

Diabetes mellitus is the most important metabolic disorder worldwide. Use of medicinal plants for lowering blood glucose is clinically important in diabetic individuals. In this respect, the effect of oral administration of aromatic water of leaves of Ficus carica on blood glucose level in diabetic rats was investigated. In this experimental study, male rats Sprague Dawley (n=80, 200-250 g), divided into two groups (40 normal and 40 diabetic surviving rats), each consisting of four subgroups (4 normal and 4 diabetic) including 10 animals each. Diabetic rats received streptozotocin (ip , 65 mg/kg). Subgroup one of each group was gavaged with vehicle (distilled water) and served as control, while subgroups 2, 3 and 4 of each group were gavaged with aromatic water of leaves of Ficus carica(extract) at doses of 0.05, 0.1, and 0.4 mg/dl, respectively. Blood glucose levels were measured 0, 3, 6, 12 and 24 hours after the administration of vehicle or the extract. Data were analyzed using repeated measure ANOVA and Dunnett t-test.